Skip to Main content Skip to Navigation
Journal articles

Divergent clonal differentiation trajectories establish CD8+ memory T cell heterogeneity during acute viral infections in humans

Abstract : The CD8+ T cell response to an antigen is composed of many T cell clones with unique T cell receptors, together forming a heterogeneous repertoire of effector and memory cells. How individual T cell clones contribute to this heterogeneity throughout immune responses remains largely unknown. In this study, we longitudinally track human CD8+ T cell clones expanding in response to yellow fever virus (YFV) vaccination at the single-cell level. We observed a drop in clonal diversity in blood from the acute to memory phase, suggesting that clonal selection shapes the circulating memory repertoire. Clones in the memory phase display biased differentiation trajectories along a gradient from stem cell to terminally differentiated effector memory fates. In secondary responses, YFV- and influenza-specific CD8+ T cell clones are poised to recapitulate skewed differentiation trajectories. Collectively, we show that the sum of distinct clonal phenotypes results in the multifaceted human T cell response to acute viral infections.
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-03345357
Contributor : Ghislain Durif Connect in order to contact the contributor
Submitted on : Wednesday, September 15, 2021 - 4:54:59 PM
Last modification on : Friday, September 17, 2021 - 3:31:26 AM

Identifiers

Collections

Citation

Jeff Mold, Laurent Modolo, Joanna Hård, Margherita Zamboni, Anton J.M. Larsson, et al.. Divergent clonal differentiation trajectories establish CD8+ memory T cell heterogeneity during acute viral infections in humans. Cell Reports, Elsevier Inc, 2021, 35 (8), pp.109174. ⟨10.1016/j.celrep.2021.109174⟩. ⟨hal-03345357⟩

Share

Metrics

Record views

42

Files downloads

87